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Because the body is efficient at excreting excess B12 through urine, there is no established tolerable upper intake level (UL) for the vitamin
Renal function categories were based on the eGFR as per Chronic Kidney Disease Epidemiology Collaboration
If youre concerned about the symptoms of vitamin B12 deficiency, consume no more alcohol than recommended by the American Heart Association and Centers for Disease Control and Prevention
The Clinical Evidence STEP 1 [1] (N=1,961, NEJM 2021, DOI: 10.1056/NEJMoa2032183): 14.9% mean weight loss over 68 weeks
P 35 days)
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