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If you flood the system with GH while eating 60 grams of protein per day, the body cannot build the muscle that drives long-term metabolic improvement
Slow titration of dose can help, as can dietary adjustments. The recent mast cell paper suggested: significantly lower doses of GLP-1RAs than presently used as starting doses for T2DM and obesity therapy might be sufficient, and even optimal, for MCAS
Adequate protein is the single biggest lever you have to protect muscle during treatment (Mayo Clinic, 2026)
Although there are currently no FDA-approved agonists for GCGR/GLP-1R and GCGR/GIPR/GLP-1R, there are still corresponding drugs undergoing clinical trials
But what exactly makes this combination so effective
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