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The exact cause of IBS remains incompletely understood, but contributing factors include visceral hypersensitivity (increased pain perception in the gut), altered gut motility, changes in the gut microbiome, low-grade inflammation, and psychological factors such as stress and anxiety

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R The conjugation itself is catalyzed by glycine N-acyltransferase (GLYAT) in the mitochondrial matrix (for glycine) or by ACNAT enzymes for other amino acids

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