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The single-pathway GLP-1 agonist semaglutide reached around 15% in its STEP 1 trial
in Spain, its current prevalence ranges between 2833%11,12 and it is a recognized as a cardiovascular risk factor and increases the mortality in this population.1315 Furthermore, in patients with DM2 and advanced CKD there are limitations in the prescription of certain antihyperglycemic drugs (e.g., metformin or sulfonylureas) and there is an increased risk of hypoglycemia with antihyperglycemic treatment,16 a complication that is associated with increased cardiovascular risk17 and hinders the achievement of glycemic control targets
It is important to speak with a healthcare provider before starting any new medication, including semaglutide, to determine if it is appropriate for you
Neuropsychopharmacology 2008, 33(9):21872199
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