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This antinociceptive profile may reflect DSIPs interaction with endogenous opioid peptide systems and/or NMDA receptor modulation at spinal cord and supraspinal pain processing sites

The study involved 130 ALS patients (74 men and 56 women) whose symptoms began within one year of enrollment and who progressed at a moderate rate, defined as a 12 point decrease in their ALSFRS-R scores over the three months preceding the trial

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The extract demonstrated notable 74.1% inhibition of HMG-CoA reductase activity in vitro , in contrast to pravastatin-mediated 91.4% inhibition, suggesting its potential as a natural beneficial substance for cholesterol management