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Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
This system is highly expressed in astrocytes, the main GSH synthesizing cells in the brain, and is regulated by various factors, including oxidative stress and inflammatory cytokines Once synthesized, GSH can be metabolized by various enzymes, including glutathione S-transferases (GSTs), which conjugate GSH with xenobiotics and endogenous electrophiles for elimination, and gamma-glutamyl transpeptidase (GGT), which cleaves GSH into its constituent amino acids and generates extracellular glutamate, a major neurotransmitter in the brain
Human platelets can activate peripheral blood B cells and increase production of immunoglobulins
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