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Hansen JS, Gustavsen S, Roshanisefat H, et al

The Sema group followed a similar high-fat diet for fourteen weeks while receiving daily subcutaneous injections of semaglutide at a dose of thirty nmol per kilogram body weight per day (Novo Nordisk, Bagsvaerd, Denmark)

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Unlike traditional RNA modification approaches that rely on solid-phase synthesis or enzymatic conversion, 2-OH acylation offers a versatile alternative for efficiently modifying both synthetic RNA and transcribed RNA, positioning it as an emerging research focus in RNA chemistry