(14) Because all trial data informing this analysis were obtained from relatively short-term trials, we performed a scenario analysis in which the efficacy of each medication on all outcomes decreased by 5% per year from 2020 to 2040
The ranking is built from peer-reviewed citation density, regulatory status, and the breadth of mechanistic data available in the published record
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The issue of obesity and insulin resistance prompted the design of a number of studies investigating the effects of antidiabetic drugs in PCOS, as reported in recent and very exhaustive reviews on the available clinical trials on glucagon-like peptide 1 receptor agonists (GLP-1RA) in PCOS [21, 23, 24]
The 12mg dose showed the greatest effect, with 8mg producing 80-82% reduction