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[35] [28] [118] It is also contraindicated in individuals with advanced arteriosclerosis (hardening of the arteries), glaucoma (increased eye pressure), hyperthyroidism (excessive production of thyroid hormone), or moderate to severe hypertension
However, delayed movement to the small intestine, where calories are absorbed, can cause fatigue, dizziness, and low blood sugar (hypoglycemia)
In the SURMOUNT-4 trial, participants achieved an average weight reduction of 20.9% with the highest tirzepatide dose, compared to 3.3% in the placebo groupa 17-fold improvement in weight loss outcomes
There is ongoing research on this subject, and currently, tirzepatide is involved in a study of women with PCOS to see if it helps to regulate their menstrual cycles
kidney or liver disease
