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Glutamate cysteine ligase (GCL) catalyzes ligation of cysteine and glutamate forming -glutamylcysteine (-GC)
246, Dec
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Although typically considered second-line therapy, SGLT2 inhibitors may have a role as initial pharmacological treatment in type 2 diabetes in conjunction with metformin in appropriately selected patients (Donnan 2019
Only when the production of free radicals overwhelms the antioxidant defense and the oxidant/antioxidant imbalance shifts in favor of oxidants, does oxidative stress develop
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