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These studies show the post-prandial increase in GLP-1 levels post MBS, without an increase in fasting GLP-1 levels
CagriSema (cagrilintide + semaglutide) has Phase 3 trial data but uses a weaker incretin backbone (just GLP-1)
& Adibekian, A
O Ipamorelin um pptido libertador da hormona do crescimento (GHRP) seletivo que atua no recetor da grelina (GHS-R1a) para estimular os somatotropos hipofisrios atravs de um mecanismo independente da sinalizao GHRH
This is significant because it is the natural site of action of the GLP1-RAs and most relevant to their uses in diabetes and appetite control
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