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While eating less to lose weight might sound appealing, skipping meals can wreak havoc on the body's metabolism, disrupt blood sugar levels, and even lead to weight gain

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Additionally, activated GPER can upregulate glucose transporters (GLUTs) and hexokinase (HK), increasing the level of aerobic glycolysis and leading to the accumulation of metabolic waste products, including lactic acid, which helps tumor cells evade immune surveillance and enhances their invasive capabilities [6, 34]

We believe that these metabolic pathways likely synergize to enhance 2,3-BPG production, a hypothesis we aim to investigate further in future research

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