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These drugs were promising early on, but many were abandoned for either failing to show clear benefits or for allegedly causing severe side effects

However, peptides with little clinical research were on the chopping block due to concerns of impurities and dangerous side effects linked to compounded treatments

doi:10.3109/1354750X.2012.715672

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Elevated levels of IL1A , IL1B , and IL1RN were observed in MAC.2 and Inf.MAC cells in TCMR, while significant IL1RL1 elevation was noted exclusively in migDCs in ABMR, suggesting a mixed inflammatory pattern of IL-1 cytokines in rejection samples ( Figure 5F )