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For example, genes with increased expression following GHK-Cu treatment often exhibit elevated histone H3 lysine 9 acetylation (H3K9ac) marks associated with transcriptionally active chromatin, while genes with reduced expression show decreased H3K9ac and increased H3K9 trimethylation (H3K9me3) repressive marks
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doi: 10.1158/1078-0432.CCR-24-3419 175 PopoviVBuriMMihailoviAAimi RemikoviMVukeljiNBatrieviMet al
112: 40-46 (1982) Mano J, Miyatake F, Hiraoka E, Tamoi M
