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A comprehensive and updated review on GLP-1 receptor agonists in a clinical perspective
Shastri, S., et al
Clinical data show that weight regain is common after GLP-1 medications are discontinued, including a STEP 1 trial extension where participants regained about two-thirds of prior weight loss one year after stopping semaglutide and lifestyle intervention
Overall, most studies had point estimates located to the right of the null line (OR = 1), indicating a higher incidence of depressive events in the GLP-1 RA group compared with the control group
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