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J Exp Med 182:178592, PMID: 7500023 Neuschwander-Tetri BA, Bellezzo JM, Britton RS, Bacon BR, Fox ES (1996) Thiol regulation of endotoxin-induced release of tumor necrosis factor a from isolated rat Kupffer cells

The appearance of a pronucleus was used as the indicator of successful activation, suggesting that the oocyte had completed meiotic maturation and was capable of initiating embryonic development independently of fertilization

Introduction of this mutation, along with reversions in previously described regions, into X(GD_L)a, X(GD_L)b and X(GD_L)c led to detectable FRET activity

Most clinical improvements appear within 12-26 weeks

For example, one of the first GLP-1 drugs that entered the U.S