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After overnight fasting, animals received PBS or test compounds (Semaglutide, Tirzepatide, or Retatrutide) in the morning, and food was provided 15 minutes post-dosing
At this point further modifications catalyzed by aldehyde dehydrogenase and aldo-keto reductase allow to obtain carboxyethylmercapturic acid and 3-hydroxypropylmercapturic acid respectively, which are escreted with urine (Fig
Nitric oxide production pathways in erythrocytes and plasma
Flagg EW, Coates RJ, Eley JW, Jones DP, Gunter EW, Byers TE et al
The evaluation process has several steps
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