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Even the STEP 1 trial, which produced remarkable results, showed a gradual trajectory rather than rapid transformation
SREBP-1c increases the expression of ACC and FAS, the enzymes that catalyze the synthesis of fatty acids and, in turn, TGs in hepatocytes (128, 129)
10.1016/j.phrs.2022.106367 44 LyuX.YanK.WangX.XuH.GuoX.ZhuH.et al (2022)
doi: 10.1038/s44319-025-00384-x 80 WestermeierFFismanEZ
It does not undergo CYP450-mediated hepatic metabolism [1]
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