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For every extra pound a person carries, the force exerted on the lower back increases significantlysome estimates suggest up to four times the amount of pressure during activities like walking or climbing stairs

Discuss the best approach with your GP or prescribing clinician based on your individual circumstances

Interestingly, retatrutide achieves something similar by activating GLP-1, GIP, and glucagon receptors through a single molecule

[1] Regarding pregnancy, tirzepatide should be discontinued when pregnancy is recognized

The boxed warning for thyroid C-cell tumors applies to both semaglutide and tirzepatide based on rodent studies not just one or the other