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Excessive dosing or dosing frequency leads to tachyphylaxis a progressive reduction in GH response as feedback loops become increasingly activated and receptor desensitization occurs at the somatotroph level
ORIGIN reported a 1.6 kg gain over 6 years with insulin glargine [46]
Anthony HV Schapira has received grants from the MRC (UK), Cure Parkinsons Trust, Parkinsons UK, EU H2020 program and Aligning Science Against Parkinsons (ASAP), MJFF, Innovate UK and consults for Capsida and Neurocrine
Frequent small meals, not large ones
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