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Both medications suppress appetite, both cause gastrointestinal side effects that can lead to dehydration, and both produce weight loss that stresses the musculoskeletal system

[200] [78] [201] In locus coeruleus norepinephrine neurons, TAAR1-dependent RhoA signaling promotes EAAT3 internalization and subsequent glutamate reuptake inhibition

Eye Effects: Cataracts and Glaucoma There is some evidence that long-term corticosteroid use can increase the risk of cataracts and glaucoma, although this is more common with oral or injected steroids

And two studies suggested that the drugs may have mental health benefits

Discuss with your provider if you have questions about which formulation suits your needs