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10.1161/01.cir.97.19.1930 Circulation
Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), disrupts the balance of glutathione within liver cells, leading to glutathione deficiencya common feature in these liver conditions
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Therefore, therapeutic approaches may need to be more nuanced, perhaps targeting specific drivers of pathological senescence, modulating the harmful components of the SASP (senomorphics), or selectively targeting only the chronically persistent senescent cells
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