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This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH
References Jarach, C
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Hepatic transcriptional profiling response to fava bean-induced oxidative stress in glucose-6-phosphate dehydrogenase-deficient mice
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