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These effects are typically mild to moderate, most pronounced in the first few days after each dose increase, and often diminish with continued use

Affinity purification mass spectrometry (AP-MS) For GFP-immunoprecipitation, HEK293 cells were transfected using x-tremeGeneTM (Roche, Rotkreuz, Switzerland) with eGFP-TMEM55B or GFP as a negative control

Overall, these data indicate that there is no clinically relevant effect of hepatic impairment on cagrilintide pharmacokinetics

The weight loss mechanisms of GLP-1 receptor agonists are multiple and synergistic: 1

The new results from REDEFINE-1 show that cagrilintide can help people lose a meaningful amount of weight and is generally well tolerated