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Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
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The latter route has a large advantage of adding circulation time to the drug, allowing long-lasting effects of the drugs, potentially reducing the administration frequency and possibly also lowering gastrointestinal complications, as currently only subcutaneous and very few oral routes have been explored
Song B, Park EY, Kim KJ, Ki SH
