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Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks
Similar results were found in a study where a broad-spectrum cocktail mixture was used to increase anxiety and depression-like behavior in mice [70]
Patients with severe gastrointestinal conditions, such as gastroparesis or other disorders that affect gastric motility, may also experience worsening symptoms since semaglutide slows gastric emptying
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