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The level of ROS in the body increases with age and as a result of negative lifestyle factors such as smoking [4] and obesity [5]

ALS is better known in the US as Lou Gehrigs disease

Ferroptosis is induced by disruption of glutathione synthesis or inhibition of glutathione peroxidase 4, exacerbated by iron, and prevented by radical scavengers such as ferrostatin-1, liproxstatin-1, and endogenous vitamin E