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: Hydrocortisone : Glucocorticoid (Corticosteroid) : Replacement therapy in adrenal insufficiency (Addisons disease) Treatment of inflammatory and allergic conditions (asthma, arthritis, dermatitis, anaphylaxis) Management of severe infections with shock (in septic shock with refractory hypotension) Topical use in eczema, rashes, and skin allergies : Hydrocortisone binds to intracellular glucocorticoid receptors alters gene expression decreases production of inflammatory mediators (prostaglandins, cytokines) anti-inflammatory & immunosuppressive effects

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Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy

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H20031265, Shanghai Fudan Fuhua Pharmaceutical Co., Ltd.) was mixed with 100 mL of normal saline for intravenous infusion, 1 day/ times, continuous treatment for 3 months