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It is noteworthy that high concentrations of PLP can regulate intracellular PLP levels by inhibiting the activity of PNPO enzyme, whereas mutant enzymes with residual activity cannot be regulated by PLP negative feedback

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Approved indications include, for instance, plaque psoriasis, rheumatoid arthritis, ankylosing spondylitis, and juvenile rheumatoid arthritis

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Rheumatol Ther (2020) 7(1):10119