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Presented at: American Diabetes Association Scientific Sessions

3.1.1 Topoisomerase inhibitors Topoisomerase inhibitors are a class of anticancer drugs whose mechanism of action is based on blocking topoisomerase enzymes from re-ligating the DNA strands after supercoiling, thus preventing DNA replication [61]

This protection extends to potential benefits for inflammatory bowel conditions, such as Crohns disease and ulcerative colitis, although further clinical studies are needed

Research limitations The most significant safety consideration involves research limitations

FBXO22 knockdown abolished BPC157-induced BACH1 upregulation (Fig