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Comparison of monoculture and coculture datasets showed little evidence of T cell activation for the T cell (no TCR and no CAR) samples, as expected (Supplementary Figs

however, there were important limitations to consider, including small sample sizes, a lack of long-term observation, the use of a single species or strain, the lack of in-depth exploration of cellular or molecular mechanisms, failure to assess other aspects of reproductive function, a lack of validation of the clinical relevance, and a failure to consider individual differences in drug dosages

For athletes, the vasodilatory effects could theoretically enhance training capacity, though this remains speculative

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Wyciszkiewicz et al., 2019)