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Beyond their islet effects, incretins exert pleiotropic actions on the brain (appetite and satiety regulation), gastrointestinal tract (delayed gastric emptying), adipose tissue (lipolysis modulation), and liver (inhibition of hepatic glucose output) (13)
Additional situations requiring discussion include: Difficulty tolerating tirzepatide's gastrointestinal effects : Severe or persistent nausea, vomiting, or diarrhea may further complicate oral medication absorption
Resveratrol treatment has been shown to reduce oxidative stress in mouse tissues by increasing the expression of antioxidants and phase II enzymes in response to the stress (Rubiolo et al., 2008
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