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tirzepatide head-to-head on mechanism, weight-loss data, side effects, and cost
King Law These cases are now being centralized under MDL No
PIONEER 9 and 10 only included patients from Japan that had a lower average body weight, were mostly male (68% to 83% of patients) and were on a combination of background therapies that is atypical for patients living in Canada (high use of TZD and Alpha-glucosidase inhibitor in PIONEER 10)
Levothyroxine dosing in the elderly targets a slightly higher TSH (up to 6 to 8 mIU/L in patients over 80), which reduces overreplacement risk and thereby limits the CYP2E1-upregulation concern
They compare milligram numbers that were never meant to be compared directly
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