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Yes, prolonged B12 deficiency can cause potentially irreversible neurological damage, including subacute combined degeneration of the spinal cord
While there is some limited evidence of the efficacy of 1,000 micrograms daily dosing of oral cyanocobalamin, this is mainly based on the correction of serum vitamin B12 levels, rather than any impact on clinical signs and symptoms[24]
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In chronic migraines, Botox is believed to function by inhibiting pain-signaling transmission between the head and neck and the central brain, where migraines are generated
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