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Allergic Reactions: Stop using Zepbound (tirzepatide) right away if you experience symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, severe rash or itching, very rapid heartbeat, problems breathing or swallowing, or fainting or feeling dizzy

This creates a mass shift of just +1 Dalton, tiny in molecular terms but enough to alter how the peptide interacts with both the GLP-1 receptor and the GIP receptor

GBD results tool

How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test identifies key variants in GIPR (rs1800437) that directly influence how your intestinal epithelium and enteric nervous system respond to GLP-1 signaling

After this, genetic testing is carried out to confirm the diagnosis