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A significant upregulation of mucosal IL23p19 , IL23R and IL17A expression was detected in patients who did not respond to anti-TNF- therapy, in association with elevated number of mucosal T cells which expressed both TNFR2 and IL-23R and demonstrated high expression of inflammatory genes and resistance to apoptosis [172]

All applications described here are preclinical and in vitro

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Then, the dose might change based on how you react and other factors

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