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The commonest side effects of GLP-1 agonists include nausea, abdominal pain, constipation, diarrhea, and vomiting
Obesity (Silver Spring) 2021;29:98594
[20] [7] This conversion is illustrated by the reduction of peroxides (via the sulfenate as an intermediate): GSH + R 2 O 2 GSOR + ROH GSOR + GSH GSSG + ROH Net reaction: 2 GSH + R 2 O 2 GSSG + 2 ROH (R = H, alkyl) and with free radicals, forming glutathionyl radicals (GS ) that may dimerize to disulfide: GSH + R RH + GS 1/2 GSSG Thiyl radicals (such as glutathionyl radicals) are themselves oxidizing species in biology, with a single-electron reduction potential sufficient for oxidation of nucleic acids, proteins and polyunsaturated lipids
2,3 These resistance patterns underscore the dynamic, adaptive nature of cancer and highlight the pressing need to decipher the underlying mechanisms that enable tumor cells to evade therapeutic pressure
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