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So far, six patients with clEDS and tissue fragility have been reported in the literature, predominantly but not exclusively of the gastrointestinal tract: (1) perforation of colonic diverticulum, development of multiple abscesses requiring partial colectomy, complicated by second small bowel perforation in a 36-year-old man

Users often report decreased joint stiffness and improved mobility within 12 weeks

10.3390/ijerph20010101 281 ThomasB

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