Glutathione decreases as we age and can also decrease with some environmental factors such as stress, infection, poor diet, or chronic disease (source)
Most patients have none beyond mild tingling, slight redness, or a little dryness in the first week, and that usually settles as your skin adjusts
Take your next dose on the regularly scheduled day
That said, for alcohol specifically, naltrexone is the tool with the track record and the approval for alcohol use disorder
By slowing down digestion, more gastrointestinal side effects can occur, including: Nausea Vomiting Diarrhea Constipation Bloating Indigestion Abdominal discomfort Sulfur burps (foul, rotten-egg-smelling burps) Acid reflux Why Side Effects Peak During Titration Medication can affect everyone differently, and so people may experience various side effects at different times while taking a drug, depending on their dosage and other factors