Some studies suggest that up to 60% of the weight lost on GLP-1s comes from lean body mass
Felix, H., Pollak, A., Gleeson, M
In the context of MASLD/MASH, analogous rebound phenomena would be expected: regression of achieved steatosis resolution and potential re-emergence of inflammatory activity and fibrogenic stimuli upon drug withdrawal
To open the suppository, separate one shell from the rest, then gently peel the flat plastic tabs apart to reveal the suppository inside the shell
The strategies for maintaining weight loss after tirzepatide typically involve either continuing the medication at a lower maintenance dose , transitioning to a less expensive option, or implementing intensive lifestyle changes to offset the lost pharmacological support