Vitamin D3 (Vit-D) is a lipid-soluble seco-steroid that exists in two forms as D 2 (ergocalciferol) derived mainly from plant sources and D 3 (cholecalciferol), which is present in higher animals 686
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A ruptured appendix spills its entire content into the peritoneum
In tumor-promoting settings, it can activate oncogenic signaling (e.g., Wnt/-catenin, ILK/AKT/mTOR, MAPK), induce inflammation/oxidative stress, and enhance proliferation, angiogenesis and metastasis [174,175,176,177]
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