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These findings indicate that hepatic toxicity associated with anabolicandrogenic steroid use can be severe and, in some cases, life-threatening (75)

In addition, more and more studies have confirmed that AH patients and animals are often accompanied by abnormal bile acid metabolism, which affects the integrity of the intestinal barrier and is closely related to the poor prognosis of the disease (Way et al., 2022)

The proximal tubule is also a major site for the regulation of the acid-base balance of the glomerular filtrate

Several possible explanations: The patent holder may not have found a pharmaceutical company willing to invest in the expensive process of clinical development

Casini, Alessandro F (2003)