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These include (i) rational drug combinations targeting parallel or converging signaling cascades, (ii) the use of allosteric inhibitors or degraders that disrupt key signaling hubs, (iii) vertical inhibition along a single pathway to prevent upstream feedback reactivation, and (iv) the application of systems biology and network modeling to predict synthetic lethal vulnerabilities
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Although its a medication for attention-deficit/hyperactivity disorder (ADHD), the FDA has approved it to treat moderate to severe binge eating disorder in adults
GLP-1 medications, including Saxenda, work by mimicking the action of the GLP-1 hormone, which is naturally made in the body
However, the therapeutic ceiling of GLP-1 monotherapy, along with the heterogeneous nature of obesity, has highlighted the significance of developing more potent agents, engaging multiple nutrient-stimulated hormone (NUSH) pathways [7]
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![PDF] Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health](https://figures.semanticscholar.org/3dfd33b87b7a620653288e23e2a1afe5b3bdaab3/2-Table1-1.png)
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