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For those who self-report a previous diagnosis, the 2- and 5-year probability of no recurrence was 38% and 3%, respectively, compared to 97% and 90% chance of no recurrence for those who did not report a previous diagnosis (Table 4 and Fig
This reduces the production of pro-swelling cytokines (TNF-, IL-1, IL-6), swelling enzymes (COX-2, iNOS), and other swelling mediators that can cause tissue damage when produced in excess
If injections cause persistent nausea, oral dosing may provide relief
Topical treatments such as capsaicin or lidocaine that can be spread on the skin or used as a patch can help relieve localized pain but can cause skin irritation, burning, and redness at the application site
