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Moreover, it remains elusive why OTA causes cytotoxicity specifically in the pericentral lobular zone that also expresses much higher levels of CYPs than the midzonal and periportal lobular regions (Ghallab et al

Interplay of mutations, alternate mechanisms, and treatment breaks in leukaemia: understanding and implications studied with stochastic models

These data correlate the behavior of the corresponding cell lines with respect to the GSH efflux stimulation observed above in the presence of verapamil (Fig