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CuHeal excludes diabetes, peripheral vascular disease, immunodeficiency, pregnancy, breastfeeding, recent immunosuppressant or cytotoxic medication use, and several wound-healing risk factors [7]
One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)
in vivo model of HnB (Vivarelli et al., 2022)
Arch Biochem Biophys (1985) 238:3042
2017;171(2):358e3719
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