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GLP-1 receptor agonists bind to receptors in the brain's appetite centers, particularly the hypothalamus, reducing hunger signals and increasing satiety after meals

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Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programmes (P40 OD010440)

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Limitations A key limitation was the rarity of trials directly comparing tirzepatide and semaglutide, leading to indirect comparisons

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