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10.2174/1381612824666180614082950 56 KatoN.KawaiT.MaedaH.NagaoT.MurakamiH.MiyazawaK.et al (1995)
Myeloid-derived suppressor cells (MDSCs) and activated tumor-associated macrophages express ARG1, which consumes arginine to form a microenvironment that is not conducive to T cells, resulting in tumor immunosuppression (Rodriguez et al., 2017
8 For example, in NSCLC, COL11A1 CAFs accumulate at tumor margins, deposit dense ECM components (COL1A1, COL3A1), and physically restrict CD8 T-cell infiltration by interacting with tumor DDR1
Expected outcomes: Improved sleep quality within 1-2 weeks
