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Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity
Localized and sustained chitosan-based doxorubicin delivery While most nanocarrier research focuses on systemic administration with the goal of achieving tumor-selective biodistribution through passive or active targeting, an alternative paradigm involves placing drug-loaded carriers directly at the tumor site either during surgical resection, through minimally invasive injection, or as topical patches for cutaneous or surgically accessible malignancies [183]
The IV route offers more predictable dosing and faster onset but carries greater risk if administered by unqualified practitioners or using unregulated formulations
Yokoyama and Miki 1995
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