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Methylenetetrahydrofolate reductase deficiency As described above, the methyl group required for remethylation of homocysteine is provided by 5-methyltetrahydrofolate formed by MTHFR (Figure 2)

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Knockdown of ATF4 by lentiviral shRNA infection reduced RNA levels of PSAT1 and SHMT2 in T315I-Bcr-Abl-32D cells (Fig

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